Recombinant Human STK24, GST-tagged, Active

• Cat.No.: STK24-362H
• Product Overview: Recombinant human MST3 (1-311) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 63 kDa.

Specification

• Cat. No.: STK24-362H
• Description: MST3 or Mammalian Sterile 20-like kinase 3 is a member of the germinal center kinase-III family. MST3 contains a conserved kinase domain at its NH(2)-terminus and a regulatory domain at its COOH-terminus. Caspase-mediated cleavage of the regulatory domain of MST3 activates its intrinsic kinase activity and leads to nuclear translocation. Expression of COOH-terminal truncated MST3 in cells results in DNA fragmentation and induction of apoptosis. MST3 can inhibit cell migration in a fashion dependent on autophosphorylation and can regulate paxillin phosphorylation through tyrosine phosphatase PTP-PEST.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 1-311.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: STK24 serine/threonine kinase 24 (STE20 homolog, yeast) [ Homo sapiens ]
• Synonyms: STK24; serine/threonine kinase 24 (STE20 homolog, yeast); MST3; STK3; MST3B; STE20; serine/threonine kinase 24; STE20-like kinase 3; sterile 20-like kinase 3; EC 2.7.11.1; MST-3; OTTHUMP00000018592; OTTHUMP00000018593; Mammalian STE20-like protein kinase 3; serine/threonine kinase 24 (Ste20, yeast homolog); Serine/threonine-protein kinase 24; STE20-like kinase MST3
• Gene ID: 8428
• mRNA Refseq: NM_001032296
• Protein Refseq: NP_001027467
• MIM: 604984
• UniProt ID: Q9Y6E0
• Chromosome Location: 13q31.2-q32.3
• Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity