Recombinant Human NEK6, GST-tagged, Active

• Cat.No.: NEK6-370H
• Product Overview: Recombinant full-length human NEK6 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=63 kDa.

Specification

• Cat. No.: NEK6-370H
• Description: NEK6 is a serine/threonine kinase that is a member of the Nek family of protein kinases that share an amino-terminal catalytic domain related to NIMA family. Nek6 is a nuclear and cytoplasmic kinase that is required for mitotic progression of human cells. Nek6 is phosphorylated and activated during M phase of the cell cycle. Inhibition of Nek6 function by either overexpression of an inactive Nek6 mutant or elimination of endogenous Nek6 by siRNA arrests cells in M phase and triggers apoptosis.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: NEK6 NIMA (never in mitosis gene a)-related kinase 6 [ Homo sapiens ]
• Synonyms: NEK6; NIMA (never in mitosis gene a)-related kinase 6; SID6-1512; NIMA-related kinase 6; OTTHUMP00000022097; putative serine-threonine protein kinase; EC 2.7.11.1
• Gene ID: 10783
• mRNA Refseq: NM_001145001
• Protein Refseq: NP_001138473
• MIM: 604043
• UniProt ID: P51955
• Chromosome Location: 9q33.3-q34.11
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein phosphatase binding; protein serine/threonine kinase activity; transferase activity; protein serine/threonine kinase activity; signal transducer activity