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Recombinant Human NEK7, GST-tagged, Active

Cat.No. : NEK7-371H
Product Overview : Recombinant full-length human NEK7 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=63 kDa.
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Cat. No. : NEK7-371H
Description : NEK7 is a member of the NIMA family of serine/threonine kinases. In contrast to the other documented NIMA-related kinases, NEK7 harbor its catalytic domain in the C-terminus of the protein. Immunofluorescence studies suggest that NEK7 is cytoplasmic and located on chromosome 1. The major protein kinase that is active on the p70 S6 kinase hydrophobic regulatory site (FXXFS/TF/Y) Thr412, was purified from rat liver and identified as NEK7. NEK7 kinase activity is rapidly and efficiently increased by serum deprivation, and may be regulated in a cell cycle-dependent manner.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : NEK7 NIMA (never in mitosis gene a)-related kinase 7 [ Homo sapiens ]
Synonyms : NEK7; NIMA (never in mitosis gene a)-related kinase 7; NIMA-related kinase 7; EC 2.7.11.1
Gene ID : 140609
mRNA Refseq : NM_133494
Protein Refseq : NP_598001
MIM : 606848
UniProt ID : Q8TDX7
Chromosome Location : 1q31.3
Function : ATP binding; magnesium ion binding; nucleotide binding; protein phosphatase binding; protein serine/threonine kinase activity; transferase activity; protein serine/threonine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you elaborate on the specific functions of NEK7 in mitosis and its contributions to spindle assembly and chromosome segregation? 04/30/2022

NEK7 is crucial for mitotic progression, contributing to spindle assembly and chromosome segregation. It phosphorylates key proteins involved in these processes, ensuring accurate distribution of genetic material during cell division.

In neurological disorders, what evidence links NEK7 to disease pathology, and what cellular processes in the nervous system involve NEK7 activity? 11/09/2021

NEK7 has been implicated in neurological disorders, with evidence linking its dysregulation to disease pathology. NEK7 activity is involved in cellular processes critical for nervous system function.

In cancer research, what evidence supports the involvement of NEK7 in tumorigenesis, and are there potential therapeutic targets associated with NEK7 dysregulation? 10/08/2020

NEK7 dysregulation is observed in various cancers, suggesting its involvement in tumorigenesis. The identification of NEK7-associated therapeutic targets holds promise for cancer treatment strategies.

How is NEK7 expression regulated, and what are the consequences of dysregulated NEK7 in cellular homeostasis and disease states? 06/19/2019

NEK7 expression is tightly regulated during the cell cycle. Dysregulation of NEK7 is associated with disruptions in cellular homeostasis and has implications in diseases such as cancer and neurodegeneration.

How does NEK7 participate in the innate immune response, particularly in the activation of the NLRP3 inflammasome, and what are the implications for inflammatory diseases? 05/02/2018

NEK7 plays a role in the innate immune response by interacting with the NLRP3 inflammasome, contributing to its activation. Dysregulation of this process is implicated in inflammatory diseases, and NEK7 is a potential therapeutic target.

Customer Reviews (3)

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Reviews
08/17/2021

    Great service, exceptional product quality

    02/13/2020

      Our lab swears by this protein. Fast shipping is a definite bonus.

      11/01/2019

        Superb quality, accompanied by excellent service.

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