Recombinant Human NEK7, GST-tagged, Active
Cat.No. : | NEK7-371H |
Product Overview : | Recombinant full-length human NEK7 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=63 kDa. |
- Specification
- Gene Information
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Cat. No. : | NEK7-371H |
Description : | NEK7 is a member of the NIMA family of serine/threonine kinases. In contrast to the other documented NIMA-related kinases, NEK7 harbor its catalytic domain in the C-terminus of the protein. Immunofluorescence studies suggest that NEK7 is cytoplasmic and located on chromosome 1. The major protein kinase that is active on the p70 S6 kinase hydrophobic regulatory site (FXXFS/TF/Y) Thr412, was purified from rat liver and identified as NEK7. NEK7 kinase activity is rapidly and efficiently increased by serum deprivation, and may be regulated in a cell cycle-dependent manner. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | NEK7 NIMA (never in mitosis gene a)-related kinase 7 [ Homo sapiens ] |
Synonyms : | NEK7; NIMA (never in mitosis gene a)-related kinase 7; NIMA-related kinase 7; EC 2.7.11.1 |
Gene ID : | 140609 |
mRNA Refseq : | NM_133494 |
Protein Refseq : | NP_598001 |
MIM : | 606848 |
UniProt ID : | Q8TDX7 |
Chromosome Location : | 1q31.3 |
Function : | ATP binding; magnesium ion binding; nucleotide binding; protein phosphatase binding; protein serine/threonine kinase activity; transferase activity; protein serine/threonine kinase activity |
Products Types
◆ Recombinant Protein | ||
Nek7-4369M | Recombinant Mouse Nek7 Protein, Myc/DDK-tagged | +Inquiry |
NEK7-3611H | Recombinant Human NEK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
NEK7-3613R | Recombinant Rat NEK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
NEK7-588H | Recombinant Human NEK7 Protein, MYC/DDK-tagged | +Inquiry |
NEK7-2818R | Recombinant Rhesus Macaque NEK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
NEK7-654HCL | Recombinant Human NEK7 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionNEK7 is crucial for mitotic progression, contributing to spindle assembly and chromosome segregation. It phosphorylates key proteins involved in these processes, ensuring accurate distribution of genetic material during cell division.
NEK7 has been implicated in neurological disorders, with evidence linking its dysregulation to disease pathology. NEK7 activity is involved in cellular processes critical for nervous system function.
NEK7 dysregulation is observed in various cancers, suggesting its involvement in tumorigenesis. The identification of NEK7-associated therapeutic targets holds promise for cancer treatment strategies.
NEK7 expression is tightly regulated during the cell cycle. Dysregulation of NEK7 is associated with disruptions in cellular homeostasis and has implications in diseases such as cancer and neurodegeneration.
NEK7 plays a role in the innate immune response by interacting with the NLRP3 inflammasome, contributing to its activation. Dysregulation of this process is implicated in inflammatory diseases, and NEK7 is a potential therapeutic target.
Customer Reviews (3)
Write a reviewGreat service, exceptional product quality
Our lab swears by this protein. Fast shipping is a definite bonus.
Superb quality, accompanied by excellent service.
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