Recombinant Human RPS6KB1, His-tagged, Active
Cat.No. : | RPS6KB1-376H |
Product Overview : | Recombinant full-length human RPS6KB1 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal His tag. MW=76 kDa. |
- Specification
- Gene Information
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Cat. No. : | RPS6KB1-376H |
Description : | P70S6K is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues. p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6k activity undergoes changes in the cell cycle and increases 20-fold in G1 cells released from G0. p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as threonine 389 a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK-1). |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [ Homo sapiens ] |
Synonyms : | RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; S6K; PS6K; S6K1; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; serine/threonine kinase 14 alpha; EC 2.7.11.1 |
Gene ID : | 6198 |
mRNA Refseq : | NM_003161 |
Protein Refseq : | NP_003152 |
MIM : | 608938 |
UniProt ID : | P23443 |
Chromosome Location : | 17q23.1 |
Pathway : | Acute myeloid leukemia; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway; TGF-beta signaling pathway; mTOR signaling pathway; Signaling by Insulin receptor |
Function : | ATP binding; nucleotide binding; peptide binding; protein binding; ribosomal protein S6 kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
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RPS6KB1-1153H | Recombinant Human RPS6KB1 Protein (R2-L525), GST tagged | +Inquiry |
Rps6kb1-5613M | Recombinant Mouse Rps6kb1 Protein, Myc/DDK-tagged | +Inquiry |
RPS6KB1-8524H | Recombinant Human RPS6KB1 protein(Met1-Leu525), GST-tagged | +Inquiry |
RPS6KB1-1915H | Recombinant Human RPS6KB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
RPS6KB1-001HCL | Recombinant Human RPS6KB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionRPS6KB1 regulates autophagy and cell survival, crucial for cellular health and response to stress.
RPS6KB1 controls protein synthesis and cell growth, playing a key role in cellular proliferation.
RPS6KB1 impacts cellular stress responses, including the repair of DNA damage and maintenance of genomic stability.
RPS6KB1 can contribute to cancer by promoting tumor cell growth and proliferation.
RPS6KB1 is a critical component of the mTOR pathway, responding to nutrient signals to regulate cell metabolism and growth.
Changes in RPS6KB1 function can affect aging processes and the development of age-related diseases.
RPS6KB1 influences metabolic processes, affecting how cells respond to conditions like obesity and diabetes.
Customer Reviews (3)
Write a reviewDependable protein purification, consistently high-quality results.
Precise mass spectrometry analysis, essential for our proteomics work.
Efficient peptide synthesis, crucial for our peptide research projects.
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