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Recombinant Human PDGFRB, GST-tagged, Active

Cat.No. : PDGFRB-386H
Product Overview : Recombinant Human full-length PDGFRB (557-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=104kDa.
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Cat. No. : PDGFRB-386H
Description : PDGFRβ (platelet-derived growth factor receptor) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRβ deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function. However, absence of PDGFRβ has no impact on major blood vessels and the heart. PDGFRβexpression and activity is elevated in several cancers and inhibition of PDGFRβ activity blocks progression of renal carcinoma in an animal model.
Source : Sf9 insect cells using baculovirus.
Sequence : 557-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Publication :
Insight on a new indolinone derivative as an orally bioavailable lead compound against renal cell carcinoma (2021)
Gene Name : PDGFRB platelet-derived growth factor receptor, beta polypeptide [ Homo sapiens ]
Synonyms : PDGFRB; platelet-derived growth factor receptor, beta polypeptide; JTK12; PDGFR; CD140B; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; CD140 antigen-like family member B; EC 2.7.10.1; CD140b; PDGF-R-beta; CD140b antigen; soluble PDGFRb variant 1
Gene ID : 5159
mRNA Refseq : NM_002609
Protein Refseq : NP_002600
MIM : 173410
UniProt ID : P09619
Chromosome Location : 5q33.1
Pathway : Calcium signaling pathway; Colorectal cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Gap junction; Glioma; MAPK signaling pathway; Melanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton
Function : ATP binding; nucleotide binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor receptor binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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