Recombinant Human Pim-1 Oncogene, GST-tagged, Active

• Cat.No.: PIM1-392H
• Product Overview: Recombinant human full-length PIM1 was expressed by baculovirus inSf9 cells usingan N-terminal GST tag. MW=62 kDa.

Specification

• Cat. No.: PIM1-392H
• Description: PIM1 is a proto-oncogene that belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from Moloney murine leukemia virus induced T-cell lymphomas in mice, PIM1 is involved in the control of cytokine-mediated cell proliferation, differentiation and survival of lymphoid and myeloid cells as well as others. Expression of PIM1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Expression of PIM1 is mediated through activation of the JAK/STAT pathway.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PIM1 pim-1 oncogene [ Homo sapiens ]
• Synonyms: PIM1; pim-1 oncogene; PIM; Proto-oncogene serine/threonine-protein kinase Pim-1; EC 2.7.11.1
• Gene ID: 5292
• mRNA Refseq: NM_002648
• Protein Refseq: NP_002639
• UniProt ID: P11309
• Chromosome Location: 6p21
• MIM: 164960
• Pathway: Acute myeloid leukemia; Jak-STAT signaling pathway
• Function: ATP binding; nucleotide binding; transferase activity; manganese ion binding; protein serine/threonine kinase activity; metal ion binding; transcription factor binding