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Cat.No.
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CABT-37089MH
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Product Overview
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Mouse monoclonal antibody to Human SUMF2.
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Antigen Description
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The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Isotype
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IgG2a
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Immunogen
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Recombinant fragment: QATSMVQLQG GRFLMGTNSP DSRDGEGPVR EATVKPFAID IFPVTNKDFR DFVREKKYRT EAEMFGWSFV FEDFVSDELR NKATQPMKSV LWWLPVEKAF , corresponding to amino acids 26-126 of Human SUMF2
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Host
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Mouse
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Species
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Human
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Formulation
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Liquid
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Concentration
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1.000 mg/ml
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Purity Detail
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Protein G purified
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Applications
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WB
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Storage buffer
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Preservative: NonePBS, pH 7.2
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
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Light chain type
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kappa
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Antigen Gene Information
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Gene name
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SUMF2 sulfatase modifying factor 2 [ Homo sapiens ]
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Official Symbol
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SUMF2
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Synonyms
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SUMF2; sulfatase modifying factor 2; sulfatase-modifying factor 2; DKFZp566I1024; C alpha formyglycine generating enzyme 2; DKFZp566I1024; DKFZp66I1024; DKFZp686L17160; DKFZp781L1035; MGC99485; Paralog of the formylglycine generating enzyme; pFGE; Sulfatase modifying factor 2; SUMF 2; OTTHUMP00000159739; OTTHUMP00000208555; OTTHUMP00000208556; OTTHUMP00000208560; OTTHUMP00000208561; OTTHUMP00000208562; OTTHUMP00000208571; OTTHUMP00000209372; OTTHUMP00000209373; OTTHUMP00000209374; C-alpha-formyglycine-generating enzy; pFGE;
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GeneID
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25870
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mRNA Refseq
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NM_001042469
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Protein Refseq
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NP_001035934
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MIM
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607940
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Uniprot ID
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Q8NBJ7
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Chromosome Location
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7q11.1
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Function
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binding; metal ion binding;
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Download Datasheet:
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