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Cat. No. |
ACVR1-2743H |
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Product Overview |
Recombinant Human
ACVR1 protein is
expressed in Nicotiana benthamiana. |
|
Description |
Activins are
homodimers or heterodimers of the various b subunit isoforms,
belonging to the TGFb family. Mature Activin a has two 116 amino
acids residues βA subunits (βA - βA). Activin exhibits a wide range
of biological activities, including mesoderm induction, neural cell
differentiation, bone remodelling, hematopoiesis, and reproductive
physiology. Activins plays a key role in the production and
regulation of hormones such as FSH, LH, GnRH and ACTH. |
|
Source |
Nicotiana
benthamiana. |
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MW |
recombinant protein
βA chain, monomeric form 14.54 kDa containing 116 amino acid
residues. |
|
Endotoxin Level |
< 0.04 EU/ μg
protein (LAL method). |
|
Formulation |
Lyophilized from a
buffer of Tris HCl 0.05M pH 7.4. |
|
Storage |
This lyophilized
preparation is stable at 2-80C, but should be kept at –200C for long
term
storage. Repeated
freezing and thawing is not recommended. |
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Gene Information
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Gene Name |
ACVR1 activin A receptor, type I [ Homo sapiens ]
|
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Synonyms
|
ACVR1; activin
A receptor, type I; OTTHUMP00000204604; OTTHUMP00000204626; TGF-B
superfamily receptor type I; activin A receptor, type II-like
kinase 2; activin receptor type I; activin receptor type-1;
activin receptor-like kinase 2; hydroxyalkyl-protein kinase;
serine/threonine-protein kinase receptor R1; EC 2.7.11.30
|
|
GeneID |
90 |
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mRNA Refseq |
NM_001105 |
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Protein Refseq |
NP_001096 |
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MIM |
102576 |
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UniProt ID |
Q04771 |
|
Chromosome Location |
2q23-q24 |
|
Pathway |
Cytokine-cytokine
receptor interaction; TGF-beta signaling pathway |
|
Function |
ATP binding;
contributes_to activin receptor activity, type I; transmembrane
receptor protein serine/threonine kinase activity; transforming
growth factor beta binding; protein homodimerization activity |
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