Recombinant Human Activin A Receptor, Type I

• Cat.No.: ACVR1-2743H
• Product Overview: Recombinant HumanACVR1 protein is expressed inNicotiana benthamiana.

Specification

• Cat. No.: ACVR1-2743H
• Description: Activins are homodimers or heterodimers of the various b subunit isoforms, belonging to the TGFb family. Mature Activin a has two 116 amino acids residues βA subunits (βA - βA). Activin exhibits a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, hematopoiesis, and reproductive physiology. Activins plays a key role in the production and regulation of hormones such as FSH, LH, GnRH and ACTH.
• Source: Nicotiana benthamiana.
• MW: recombinant protein βA chain, monomeric form 14.54 kDa containing 116 amino acid residues.
• Endotoxin Level: < 0.04 EU/ μg protein (LAL method).
• Formulation: Lyophilized from a buffer of Tris HCl 0.05M pH 7.4.
• Storage: This lyophilized preparation is stable at 2-8⁰C, but should be kept at –20⁰C for long termstorage. Repeated freezing and thawing is not recommended.

Gene Information

• Gene Name: ACVR1 activin A receptor, type I [ Homo sapiens ]
• Synonyms:
  ACVR1; activin A receptor, type I; OTTHUMP00000204604; OTTHUMP00000204626; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; activin receptor type I; activin receptor type-1; activin receptor-like kinase 2; hydroxyalkyl-protein kinase; serine/threonine-protein kinase receptor R1; EC 2.7.11.30
• Gene ID: 90
• mRNA Refseq: NM_001105
• Protein Refseq: NP_001096
• MIM: 102576
• UniProt ID: Q04771
• Chromosome Location: 2q23-q24
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: ATP binding; contributes_to activin receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity; transforming growth factor beta binding; protein homodimerization activity