Active Recombinant Human SIK1 Protein, His-tagged
Cat.No. : | SIK1-431H |
Product Overview : | Recombinant Human SIK1(1-303) fused with His tag was expressed in baculovirus infected Sf9 cells. |
- Specification
- Gene Information
- Related Products
Description : | SIK is a protein kinase that is involved in regulating AMPK-related kinases. SIK may mediate the physiological effects of LKB1, including its tumour suppressor function. SIK is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Form : | Buffered aqueous glycerol solution |
Bio-activity : | 296 nmol/min·mg |
Molecular Mass : | ~36 kDa |
Quality Control Test : | ≥80% (SDS-PAGE) |
Notes : | After opening, aliquot into smaller quantities and store at -70 centigrade. Avoid repeating handling and multiple freeze/thaw cycles |
Storage : | Store at -70 centigrade |
Concentration : | 0.1 ug/ul |
Gene Name : | SIK1 salt inducible kinase 1 [ Homo sapiens (human) ] |
Official Symbol : | SIK1 |
Synonyms : | MSK; SIK; SIK-1; SNF1LK |
Gene ID : | 150094 |
mRNA Refseq : | 173354 |
Protein Refseq : | NP_775490 |
MIM : | 605705 |
UniProt ID : | P57059 |
Chromosome Location : | 21q22.3 |
Products Types
◆ Recombinant Protein | ||
SIK1-8172M | Recombinant Mouse SIK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SIK1-5061R | Recombinant Rat SIK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SIK1-6248C | Recombinant Chicken SIK1 | +Inquiry |
SIK1-432H | Recombinant Human SIK1 protein, His-tagged | +Inquiry |
SIK1-15134M | Recombinant Mouse SIK1 Protein | +Inquiry |
◆ Lysates | ||
SIK1-1842HCL | Recombinant Human SIK1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1624 | SIK1 Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulation of SIK1 has been implicated in cancer. It can influence cell proliferation and survival by affecting the activity of transcription factors involved in cell cycle control and apoptosis.
SIK1 plays a role in adipose tissue metabolism by modulating the activity of transcription factors involved in lipogenesis and lipolysis. Dysregulation may contribute to metabolic disorders like obesity and insulin resistance.
SIK1, or Salt-Inducible Kinase 1, is involved in the regulation of cellular responses to various stimuli, including stress, metabolism, and inflammation.
SIK1 regulates energy homeostasis by phosphorylating and modulating the activity of key metabolic regulators, such as cAMP response element-binding protein (CREB) and class IIa histone deacetylases.
SIK1 is activated in response to environmental stressors, such as osmotic stress. It regulates stress signaling pathways through the phosphorylation of downstream effectors, modulating cellular stress responses.
Customer Reviews (3)
Write a reviewOur lab swears by this product! It's a versatile and reliable tool for our experiments.
The quality control is evident in the data precision we achieve.
As a researcher, I can't live without this product. Makes my experiments more accurate and efficient.
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