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Recombinant Human STE20-like Kinase (Yeast), GST-tagged, Active

Cat.No. : SLK-432H
Product Overview : Recombinant full-length human SLK was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 180 kDa.
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Cat. No. : SLK-432H
Description : SLK or LOSK is a Ste20-like protein kinase that associates with microtubule and centrosome. Inhibition of SLK activity by dominant-negative mutant or RNAi leads to unfocused microtubule arrangement indicating that SLK is needed for microtubule organization and for the proper localization of Golgi complex. Expression of v-Src can down-regulate SLK activity through the involvement of CK2 which can directly phosphorylate and inhibit SLK activity whereas inhibition of CK2 in v-Src-transformed cells results in normal SLK activity. CK2 and SLK can be co-localized in fibroblasts spreading on fibronectin-coated substrates.
Source : Sf9 insect cells using baculovirus.
Sequence : Full length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : SLK STE20-like kinase (yeast) [ Homo sapiens ]
Synonyms : SLK; STE20-like kinase (yeast); LOSK; STK2; se20-9; KIAA0204; MGC133067; bA16H23.1; serine/threonine kinase 2; Long Ste20-like Kinase; CTCL tumor antigen se20-9; Ste20-related serine/threonine kinase; SNF1 sucrose nonfermenting like kinase; SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase; EC 2.7.11.1; OTTHUMP00000020426; OTTHUMP00000059183; Hslk; STE20-like kinase; STE20-related kinase; STE20-related serine/threonine-protein kinase; Serine/threonine-protein kinase 2; Ste20-related serine/threonine kinase; serine/threonine kinase 2
Gene ID : 9748
mRNA Refseq : NM_014720
Protein Refseq : NP_055535
UniProt ID : Q9H2G2
Chromosome Location : 10q24.33
Function : ATP binding; DNA binding; nuclease activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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