Recombinant Human TANK-binding Kinase 1, GST-tagged, Active
Cat.No. : | TBK1-443H |
Product Overview : | Recombinant full-length human TBK1 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 105 kDa. |
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Cat. No. : | TBK1-443H |
Description : | TBK1, also known as NAK or NFkB-activating kinase, is an upstream protein kinase that can phosphorylate and activate the IkB kinases. Activation of IkB kinases allows the phosphorylation of IkB protein which is then degraded via the ubiquitination pathway. This mechanism allows the activation of the NFkB transcriptional complex. TBK1 is a specific upstream regulator of IkB kinases and can also interact and the IkB protein TANK. TBK1 is a component of the virus-activated kinase that phosphorylate IRF3 and IRF7 allowing their dimerization and translocation to the nucleus, where they induce transcription of interferon. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Publication : |
Quantitation of the Dynamic Profiles of the Innate Immune Response Using Multiplex Selected Reaction Monitoring–Mass Spectrometry (2013)
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Gene Name : | TBK1 TANK-binding kinase 1 [ Homo sapiens ] |
Synonyms : | TBK1; TANK-binding kinase 1; NAK; T2K; FLJ11330; NF-kB-activating kinase; EC 2.7.11.1; NF-kappa-B-activating kinase; Serine/threonine-protein kinase TBK1 |
Gene ID : | 29110 |
mRNA Refseq : | NM_013254 |
Protein Refseq : | NP_037386 |
MIM : | 604834 |
UniProt ID : | Q9UHD2 |
Chromosome Location : | 12q14.1 |
Pathway : | RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway |
Function : | ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTBK1 is a critical component of the cGAS-STING pathway, which senses cytosolic DNA and triggers type I interferon responses. TBK1 phosphorylates STING, initiating downstream signaling events.
TBK1 is involved in selective autophagy processes by phosphorylating autophagy receptors and initiating the clearance of damaged organelles or pathogens. This contributes to maintaining cellular homeostasis and responding to stress conditions.
TBK1 plays a dual role in inflammation, acting as both a pro-inflammatory and anti-inflammatory mediator. Dysregulation of TBK1 is implicated in autoimmune disorders and inflammatory diseases, highlighting its complex regulatory role.
TBK1 dysfunction has been associated with neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The precise mechanisms linking TBK1 to these diseases are areas of active research.
TBK1 plays a crucial role in the activation of the transcription factor IRF3, leading to the induction of type I interferons. This activation is triggered by the recognition of viral nucleic acids or other pathogen-associated molecular patterns.
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