Recombinant Human TEK Tyrosine Kinase, Endothelial, GST-tagged, Active
Cat.No. : | TEK-445H |
Product Overview : | Recombinant human TIE 2 (771-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 61 kDa. |
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- Gene Information
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Cat. No. : | TEK-445H |
Description : | TIE 2 or TEK is a receptor tyrosine kinase that is expressed principally on vascular endothelium. Disrupting TIE 2 function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TIE 2 receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TIE 2 kinase domain and are part of the cellular responses that mediate TIE 2 function. TIE 2 expression is upregulated in the endothelium of vascular "hot spots" in human breast cancer specimens. However, TIE 2 is also overexpressed in areas of active angiogenesis in normal tissues. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 771-end. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | TEK TEK tyrosine kinase, endothelial [ Homo sapiens ] |
Synonyms : | TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; soluble TIE2 variant 1; soluble TIE2 variant 2; p140 TEK |
Gene ID : | 7010 |
mRNA Refseq : | NM_000459 |
Protein Refseq : | NP_000450 |
MIM : | 600221 |
UniProt ID : | Q02763 |
Chromosome Location : | 9p21 |
Pathway : | Hemostasis; Signaling in Immune system |
Function : | ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity |
Products Types
◆ Lysates | ||
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TEK-1511MCL | Recombinant Mouse TEK cell lysate | +Inquiry |
TEK-1065CCL | Recombinant Cynomolgus TEK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.
The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.
The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.
The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.
The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.
Customer Reviews (3)
Write a reviewOutstanding service! Staff expertise helped us choose the perfect protein.
Seamless delivery process—ordered, received, and ready for experiments.
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