Recombinant Human NTRK1, GST-tagged, Active
Cat.No. : | NTRK1-448H |
Product Overview : | Recombinant human TRKA (440-end) was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 66kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | NTRK1-448H |
Description : | TRKA is a member of the trk proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 440-end. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ] |
Synonyms : | NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; p140-TrkA; DKFZp781I14186; Trk-A; Oncogene TRK; tyrosine kinase receptor A; high affinity nerve growth factor receptor; EC 2.7.10.1 |
Gene ID : | 4914 |
mRNA Refseq : | NM_001007792 |
Protein Refseq : | NP_001007793 |
MIM : | 191315 |
UniProt ID : | P04629 |
Chromosome Location : | 1q21-q22 |
Pathway : | Apoptosis; Endocytosis; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Thyroid cancer; Signalling by NGF |
Function : | ATP binding; neurotrophin receptor activity; nucleotide binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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