Recombinant Human Unc-51-Like Kinase 1 (C. elegans), GST-tagged, Active
Cat.No. : |
ULK1-255H |
Product Overview : |
Recombinant human ULK1 (1-649) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 125 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : |
ULK1-255H |
Description : |
ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner. |
Source : |
Sf9 insect cells using baculovirus. |
Sequence : |
1-649. |
Applications : |
Kinase Assay, Western Blot. |
Storage And Stability : |
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : |
ULK1 unc-51-like kinase 1 (C. elegans) [ Homo sapiens ] |
Synonyms : |
unc-51-like kinase 1 (C. elegans); ATG1; UNC51; Unc51.1; FLJ38455; FLJ46475; ULK1; Unc-51-like kinase 1; ATG1 autophagy related 1 homolog; EC 2.7.11.1; KIAA0722; unc-51 (C. elegans)-like kinase 1 |
Gene ID : |
8408 |
mRNA Refseq : |
NM_003565 |
Protein Refseq : |
NP_003556 |
MIM : |
603168 |
UniProt ID : |
O75385 |
Chromosome Location : |
12q24.3 |
Pathway : |
Regulation of autophagy; mTOR signaling pathway |
Function : |
ATP binding; nucleotide binding; protein complex binding; protein serine/threonine kinase activity; transferase activity |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.