"A2M" Related Products

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Native Human A2M

Cat.No.: A2M-27054TH
Product Overview: Full length native mature Human alpha 2 Macroglobulin purified from Human Plasma; amino acids 24-1474, 725 kDa Homotetramer ,
Description: Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
Tissue specificity: Secreted in plasma.
Form: Lyophilised
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: Glycine, 30mM Sodium phosphate, pH 7.0
Storage: Shipped at 4°C. Store at -20oC.
Sequence Similarities: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Gene Name: A2M alpha-2-macroglobulin [ Homo sapiens ]
Official Symbol: A2M
Synonyms: A2M; alpha-2-macroglobulin; CPAMD5; FWP007; S863 7;
Gene ID: 2
mRNA Refseq: NM_000014
Protein Refseq: NP_000005
MIM: 103950
Uniprot ID: P01023
Chromosome Location: 12p13.31
Pathway: Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem;
Function: enzyme binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; protein binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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