Recombinant full length Human ABCB7 with N terminal proprietary tag; Predicted MWt 104.76 kDa.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the MDR/TAP subfamily.Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol.With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis.Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
715 amino acids
104.760kDa inclusive of tags
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids:
PQWRPHQLGALGTARAYQQIPESLKSITWQRLGKGNSGQF LDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDT RKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVV PFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYG VSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLD LGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFE VMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTR FRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYD GFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLAS QGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQA LIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNV HFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRL LFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVL FHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHG YDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATS SLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEII VLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDN PKWEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.Contains 1 ABC transmembrane type-1 domain.Contains 1 ABC transporter domain.