"ACACA" Related Products

Recombinant Human ACACA, His-tagged

Cat.No.: ACACA-26053TH
Product Overview: Recombinant fragment corresponding to amino acids 39-2346 of Human Acetyl Coenzyme A carboxylase alpha with C terminal His tag expressed in a Baculovirus infected Sf9 cell expression system, 266.5kDa.
Description: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5 sequence and encoding distinct isoforms have been found for this gene.
Conjugation: HIS
Tissue specificity: Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.05% Tween 20, 50mM Tris HCl, 3mM DTT, 150mM Sodium chloride, 0.1mM EDTA, 0.1mM EGTA, pH 7.5
Storage: Store at -20°C, Stable for 6 months at -20°C
Sequence Similarities: Contains 1 ATP-grasp domain.Contains 1 biotin carboxylation domain.Contains 1 biotinyl-binding domain.Contains 1 carboxyltransferase domain.
Gene Name: ACACA acetyl-CoA carboxylase alpha [ Homo sapiens ]
Official Symbol: ACACA
Synonyms: ACACA; acetyl-CoA carboxylase alpha; ACAC, ACC, acetyl Coenzyme A carboxylase alpha; acetyl-CoA carboxylase 1; ACC1; acetyl CoA carboxylase 1;
Gene ID: 31
mRNA Refseq: NM_198834
Protein Refseq: NP_942131
MIM: 200350
Uniprot ID: Q13085
Chromosome Location: 17q21
Pathway: AMPK signaling, organism-specific biosystem; ChREBP activates metabolic gene expression, organism-specific biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty Acyl-CoA Biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, organism-specific biosystem;
Function: ATP binding; acetyl-CoA carboxylase activity; biotin binding; biotin carboxylase activity; ligase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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