| Description : |
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs).IREs are stem-loop structures found in the 5 UTR of ferritin mRNA, and in the 3 UTR of transferrin receptor mRNA.The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA.Thus, IREB1 plays a central role in cellular iron homeostasis.It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. |
| Protein length : |
889 amino acids |
| Conjugation : |
HIS |
| Molecular Weight : |
100.800kDa inclusive of tags |
| Source : |
E. coli |
| Form : |
Liquid |
| Purity : |
>90% by SDS-PAGE |
| Storage buffer : |
Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 2mM DTT, 100mM Sodium chloride, pH 8.0 |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Sequences of amino acids : |
MGSSHHHHHHSSGLVPRGSHMGSMS NPFAHLAEPLDPVQPGKKFFNLNKL EDSRYGRLPFSIRVLLEAAIRNCDE FLVKKQDIENILHWNVTQHKNIEVP FKPARVILQDFTGVPAVVDFAAMRD AVKKLGGDPEKINPVCPADLVIDHS IQVDFNRRADSLQKNQDLEFERNRE RFEFLKWGSQAFHNMRIIPPGSGII HQVNLEYLARVVFDQDGYYYPDSLV GTDSHTTMIDGLGILGWGVGGIEAE AVMLGQPISMVLPQVIGYRLMGKPH PLVTSTDIVLTITKHLRQVGVVGKF VEFFGPGVAQLSIADRATIANMCPE YGATAAFFPVDEVSITYLVQTGRDE EKLKYIKKYLQAVGMFRDFNDPSQD PDFTQVVELDLKTVVPCCSGPKRPQ DKVAVSDMKKDFESCLGAKQGFKGF QVAPEHHNDHKTFIYDNTEFTLAHG SVVIAAITSCTNTSNPSVMLGAGLL AKKAVDAGLNVMPYIKTSLSPGSGV VTYYLQESGVMPYLSQLGFDVVGYG CMTCIGNSGPLPEPVVEAITQGDLV AVGVLSGNRNFEGRVHPNTRANYLA SPPLVIAYAIAGTIRIDFEKEPLGV NAKGQQVFLKDIWPTRDEIQAVERQ YVIPGMFKEVYQKIETVNESWNALA TPSDKLFFWNSKSTYIKSPPFFENL TLDLQPPKSIVDAYVLLNLGDSVTT DHISPAGNIARNSPAARYLTNRGLT PREFNSYGSRRGNDAVMARGTFANI RLLNRFLNKQAPQTIHLPSGEILDV FDAAERYQQAGLPLIVLAGKEYGAG SSRDWAAKGPFLLGIKAVLAESYER IHRSNLVGMGVIPLEYLPGENADAL GLTGQERYTIIIPENLKPQMKVQVK LDTGKTFQAVMRFDTDVELTYFLNG GILNYMIRKMAK |
| Sequence Similarities : |
Belongs to the aconitase/IPM isomerase family. |
