Recombinant full length Human ACOX1 with N-Terminal proprietary tag. Mol Wt 98.71 kDa inclusive of tag.
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
660 amino acids
98.710kDa inclusive of tags
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids:
MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMI LNDPDFQHEDLNFLTRSQRYEVAVRKSAIMVKKMREFGIA DPDEIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQATAEQQ ERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETIATYDPET QEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCY GLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYL KMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVF VRSFLVGEAARALSKACTIAIRYSAVRHQSEMKPGEPEPQ ILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIG QGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHG YSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYD QVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSP ESLTEAYKLRAARLVEIAAKNLQKEVIHRKSKEVAWNLTS VDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCL LYSLYGISQNAGDFLQGSIMTEPQITQVNQRVKELLTLIR SDAVALVDAFDFQDVTLGSVLGRYDGNVYENLFEWAKNSP LNKAEVHESYKHLKSLQSKL
Belongs to the acyl-CoA oxidase family.