| Description : |
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. |
| Form : |
Liquid |
| Purity : |
Immunogen affinity purified |
| Storage buffer : |
Preservative: NoneConstituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5 |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
| Sequences of amino acids : |
MWAPPAAIMGDGPTKKVGNQAPLQT QALQTASLRDGPAKR AVWVRHTSSEPQEPTESKAAKERPK QEVTKAVVVDLGT GYCKCGFAGLPRPTHKISTTVGKPY METAKTGDNRKET FVGQELNNTNVHLKLVNPLRHGIIV DWDTVQDIWEYLFRQEMKIAPEEHA VLVSDPPLSPHTNREKYAEMLFEAF NTP AMHIAYQSRLSMYSYGRTSGLVVEV GHGVSYVVPIYEG YPLPSITGRLDYAGSDLTAYLLGLL NSAGNEFTQDQMG IVEDIKKKCCFVALDPIEEKKVPLS EHTIRYVLPDGKEIQ LCQERFLCSEMFFKPSLIKSMQLGL HTQTVSCLNKCDI ALKRDLMGNILLCGGSTMLSGFPNR LQKELSSMCPNDT PQVNVLPERDSAVWTGGSILASLQG FQPLWVHRFEYEE HGPFFLYRRCF |
