Recombinant full length Human Activin Receptor Type IIB, aa 1-303 according toAAH96245.1, with N terminal proprietary tag; 59.4 incluisive of tag.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
303 amino acids
59.400kDa inclusive of tags
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids:
MNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCH VAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLL KSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDE YMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPG LAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTT SDCLVSLVTSVTNVDLPPKESSI
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 protein kinase domain.