Recombinant fragment, corresponding to amino acids 144-503 of Human ACVRL1,expressed by baculovirus in Sf9 insect cells using an N terminal proprietary tag.
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
The specific activity of ACVRL1-26214TH was determined to be 22 nmol/min/mg by activity assay.
Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids:
RRRQEKQRGL HSELGESSLI LKASEQGDSM LGDLLDSDCT TGSGSGLPFL VQRTVARQVA LVECVGKGRY GEVWRGLWHG ESVAVKIFSS RDEQSWFRET EIYNTVLLRH DNILGFIASD MTSRNSSTQL WLITHYHEHG SLYDFLQRQT LEPHLALRLA VSAACGLAHL HVEIFGTQGK PAIAHRDFKS RNVLVKSNLQ CCIADLGLAV MHSQGSDYLD IGNNPRVGTK RYMAPEVLDE QIRTDCFESY KWTDIWAFGL VLWEIARRTI VNGIVEDYRP PFYDVVPNDP SFEDMKKVVC VDQQTPTIPN RLAADPVLSG LAQMMRECWY PNPSARLTAL RIKKTLQKIS NSPEKPKVIQ
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain.