Recombinant full length Human ADRB2CAM with an N-terminal FLAG tag fused at the C-terminus to the N-terminus of GsαL via a His tag, expressed in Sf9 insect cells.
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Activity: 2.4 - 4.9 pmol/mg
Preservative: NoneConstituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.