Recombinant full length Human alpha 1 Fetoprotein with N terminal propietary tag; Predicted MWt 93.06 inclusive of tag.
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
609 amino acids
93.060kDa inclusive of tags
Plasma. Synthesized by the fetal liver and yolk sac.
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids:
MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAE ISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPT GDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSE EGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRE TFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAE NAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRT FQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDV LDCLQDGEKIMSYICSQQDTLSNKITECCKLTTLERGQ CIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLA SFVHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENP LECQDKGEEELQKYIQESQALAKRSCGLFQKLGEYYLQNA FLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDK LLACGEGAADIIIGHLCIRHEMTPVNTGVGQCCTSSYANR RPCFSSLVVDETYVPPAFSDDKFIFHKDLCQAQGVALQ TMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQ EQEVCFAEEGQKLISKTRAALGV
Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.