Recombinant Human AGER, FLAG-tagged

Cat.No.: AGER-31159TH
Product Overview: Recombinant fragment of Human RAGE (amino acids 23-342) with C terminal DDDDK tag; 331aa, 35.2kDa.
Description: The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimers disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
Protein length: 320 amino acids
Conjugation: FLAG
Molecular Weight: 35.200kDa inclusive of tags
Source: HEK 293 cells
Tissue specificity: Endothelial cells.
Form: Lyophilised:Add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a
Purity: >95% by SDS-PAGE
Storage buffer: pH: 7.50Constituents:0.79% Tris HCl, 0.29% Sodium chloride
Storage: Shipped at 4°C. Store at -20oC.
Sequences of amino acids: AQNITARIGE PLVLKCKGAP KKPPQRLEWK LNTGRTEAWK VLSPQGGGPW DSVARVLPNG SLFLPAVGIQ DEGIFRCQAM NRNGKETKSN YRVRVYQIPG KPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGK PLVPNEKGVS VKEQTRRHPE TGLFTLQSEL MVTPARGGDP RPTFSCSFSP GLPRHRALRT APIQPRVWEP VPLEEVQLVV EPEGGAVAPG GTVTLTCEVP AQPSPQIHWM KDGVPLPLPP SPVLILPEIG PQDQGTYSCV ATHSSHGPQE SRAVSISIIE PGEEGPTAGS VGGSGLGTLA AAADYKDDDDK
Sequence Similarities: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Gene Name: AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]
Official Symbol: AGER
Synonyms: AGER; advanced glycosylation end product-specific receptor; RAGE;
Gene ID: 177
mRNA Refseq: NM_001136
Protein Refseq: NP_001127
MIM: 600214
Uniprot ID: Q15109
Chromosome Location: 6p21.3
Pathway: Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem;
Function: S100 alpha binding; advanced glycation end-product receptor activity; protein binding; receptor activity; receptor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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