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Recombinant Human AGT

Cat.No.: AGT-26571TH
Product Overview: Recombinant full length Human Angiotensinogen protein with an N terminal proprietary tag; predicted mwt: 79.46 kDa inclusive of tag.
Description: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Protein length: 485 amino acids
Molecular Weight: 79.460kDa inclusive of tags
Source: Wheat germ
Tissue specificity: Expressed by the liver and secreted in plasma.
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHP FHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVD EKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGM HSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQA ILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQ AQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLD FTELDVAAEKIDRFMQAVTGWKTGCSLTGASVDSTLAFNT YVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQ HWSDIQDNFSVTQVSFTESACLLLIQPHYASDLDKVEGLT FQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAE LPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPT ESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVAN PLSTA
Sequence Similarities: Belongs to the serpin family.
Gene Name: AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ]
Official Symbol: AGT
Synonyms: AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); SERPINA8; angiotensinogen; alpha 1 antiproteinase; antitrypsin;
Gene ID: 183
mRNA Refseq: NM_000029
Protein Refseq: NP_000020
Uniprot ID: P01019
Chromosome Location: 1q42.2
Pathway: ACE Inhibitor Pathway, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function: acetyltransferase activator activity; growth factor activity; hormone activity; hormone activity; serine-type endopeptidase inhibitor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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