Recombinant Mouse Lipase, Hepatic, His-tagged
Cat.No. : | Lipc-391M |
Product Overview : | Recombinant Mouse LIPC was expressed inE.Coliusing an N-terminal His tag. MW=26 kDa. |
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- Gene Information
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Cat. No. : | Lipc-391M |
Description : | Hepatic lipase, also known as LIPC, is a lipolytic enzyme synthesized and secreted by hepatocytes that bind extracellularly to the parenchymal and endothelial cell surfaces in the space of Disse. Clinical studies have shown that an inverse relationship exists between the LIPC activity in postheparin plasma and plasma HDL-C concentrations, suggesting that it can serve as a marker for cardiovascular disease risk and may serve as a target for therapy. The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence. |
Source : | E.Coli. |
Sequence : | 91 - 510. |
Purity : | ~95%. |
Specific Activity : | n/a. |
Applications : | This recombinant protein can be used for WB, ELISA, MS and neutralization assays. |
Buffer : | 1X PBS containing 0.1% SDS. |
Storage : | Store at -70?C. As with any protein, exposing LIPC recombinant protein to repeated freeze/thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
SDS-PAGE : | SDS-PAGE analysis of recombinant LIPC on Coomassie Blue-stained 12% SDS-PAGE gel. |
Gene Name : | Lipc lipase, hepatic [ Mus musculus ] |
Synonyms : | Lipc; lipase, hepatic; HL; Hpl; AI256194; lipase C; hepatic lipase; EC 3.1.1.3 |
Gene ID : | 15450 |
mRNA Refseq : | NM_008280 |
Protein Refseq : | NP_032306 |
UniProt ID : | P27656 |
Chromosome Location : | 9 D; 9 39.0 cM |
Pathway : | Glycerolipid metabolism; Metabolic pathways |
Function : | catalytic activity; heparin binding; hydrolase activity; triglyceride lipase activity; lipase activity |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionGenetic variations in the LIPC gene can influence enzyme activity, impacting lipid metabolism. Certain variants are associated with an increased risk of metabolic disorders such as dyslipidemia and insulin resistance.
LIPC contributes to lipid homeostasis by breaking down lipids, regulating their levels in the bloodstream. Dysregulation of LIPC activity is associated with imbalances in lipid profiles and an increased risk of cardiovascular diseases.
The expression of the LIPC gene is influenced by various factors, including dietary fat intake, hormonal signals, and genetic predisposition. Transcriptional regulators and epigenetic modifications also play a role.
LIPC interacts with various proteins in lipid metabolism pathways. Disruptions in these interactions can lead to impaired lipid processing, contributing to metabolic disorders and cardiovascular diseases.
Techniques such as RT-PCR, Western blotting, and enzyme assays are commonly used to study LIPC expression and activity. Additionally, advanced methods like mass spectrometry provide insights into post-translational modifications.
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