"ANGPT1" Related Products

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Recombinant Human ANGPT1, His-tagged

Cat.No.: ANGPT1-26922TH
Product Overview: Human Recombinant Full Length Angiopoietin 1 derived from HeLa cells with a C terminal histidine tag, 60-70 kDa.
Description: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Conjugation: HIS
Form: Lyophilised:Reconstitution should be done in water to a concentration of 0.1-1.0mg/ml.
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 5% Trehalose, 200mM Sodium chloride, 20mM Sodium phosphate, pH 7.5
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein.
Sequence Similarities: Contains 1 fibrinogen C-terminal domain.
Gene Name: ANGPT1 angiopoietin 1 [ Homo sapiens ]
Official Symbol: ANGPT1
Synonyms: ANGPT1; angiopoietin 1; angiopoietin-1; Ang1; KIAA0003;
Gene ID: 284
mRNA Refseq: NM_001146
Protein Refseq: NP_001137
MIM: 601667
Uniprot ID: Q15389
Chromosome Location: 8q23.1
Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function: receptor tyrosine kinase binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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