Human Recombinant Full Length Angiopoietin 1 derived from HeLa cells with a C terminal histidine tag, 60-70 kDa.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Lyophilised:Reconstitution should be done in water to a concentration of 0.1-1.0mg/ml.
Preservative: NoneConstituents: 5% Trehalose, 200mM Sodium chloride, 20mM Sodium phosphate, pH 7.5
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids:
Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein.
Contains 1 fibrinogen C-terminal domain.