Recombinant Human ANGPTL3, FLAG-tagged

• Cat.No.: ANGPTL3-26574TH
• Product Overview: Recombinant full length Human ANGPTL3 fused at the C terminus to a DDDDK tag; mwt: 60 kDa by SDS PAGE.

Specification

• Description: The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
• Protein length: 460 amino acids
• Conjugation: FLAG
• Molecular Weight: 60.000kDa inclusive of tags
• Source: HEK 293 cells
• Tissue specificity: Expressed principally in liver. Weakly expressed in kidney.
• Biological activity: Activates ERK phosphorylation in THP-1 cells.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 fibrinogen C-terminal domain.

Gene Information

• Gene Name: ANGPTL3 angiopoietin-like 3 [ Homo sapiens ]
• Official Symbol: ANGPTL3
• Synonyms: ANGPTL3; angiopoietin-like 3; ANGPT5; angiopoietin-related protein 3; angiopoietin 5
• Gene ID: 27329
• mRNA Refseq: NM_014495
• Protein Refseq: NP_055310
• MIM: 604774
• Uniprot ID: Q9Y5C1
• Chromosome Location: 1p31.1-p22.3
• Pathway: Integrins in angiogenesis, organism-specific biosystem
• Function: cell surface binding; enzyme inhibitor activity; growth factor activity; integrin binding; phospholipase inhibitor activity