Recombinant fragment corresponding to amino acids 224-460 of Human ANGPTL3 with an N terminal DDDDK tag; MWt 35 kDa by SDS PAGE.
The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
237 amino acids
35.000kDa inclusive of tags
Expressed principally in liver. Weakly expressed in kidney.
Preservative: NoneConstituents: PBS
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Contains 1 fibrinogen C-terminal domain.