Recombinant full length Human FE65 with N terminal proprietary tag; Predicted MWt 103.95 kDa.
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimers disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene products nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimers disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.
708 amino acids
103.950kDa inclusive of tags
Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids:
MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKL QATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRA ATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEE EEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPR EHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQW EPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDE PSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQ LSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQA LLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSK LVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVI NGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPN AASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVA RRVGWTVRRGVQSLWGSLKPKRLGAHTP
Contains 2 PID domains.Contains 1 WW domain.