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Recombinant Human Activating Transcription Factor 2, GST-tagged

Cat.No. : ATF2-1432H
Product Overview : Recombinant human ATF2 (1-254) was expressed inE. colicells using a N-terminal GST tag. MW=55kDa.
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  • Gene Information
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Cat. No. : ATF2-1432H
Description : Activating transcription factor (ATF)-2, also designated CRE-BP1, is a member of the ATF/cyclic AMP-responsive element binding protein family of transcription factors. ATF2 has two unique characteristics: it mediates the adenovirus E1A-induced trans-activation and forms a heterodimer with c-Jun. ATF2 is a target of the JNK signal transduction pathway. ATF2 is phosphorylated by JNK on two closely spaced threonine residues within the NH2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. Furthermore, p38 MAPK can also phosphorylate ATF2.
Source : E. coli.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : ATF2 activating transcription factor 2 [ Homo sapiens ]
Synonyms : ATF2; activating transcription factor 2; HB16; CREB2; TREB7; CRE-BP1; MGC111558; cAMP responsive element binding protein 2; clic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; cAMP response element-binding protein CRE-BP1; Cyclic AMP-responsive element-binding protein 2; CREB-2
Gene ID : 1386
mRNA Refseq : NM_001880
Protein Refseq : NP_001871
UniProt ID : P15336
Chromosome Location : 2q32
MIM : 123811
Pathway : MAPK signaling pathway; Signaling in Immune system
Function : RNA polymerase II transcription factor activity; metal ion binding; protein dimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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