Recombinant Human ATIC

• Cat.No.: ATIC-27034TH
• Product Overview: Recombinant full length Human ATIC with N terminal proprietary tag; Predicted MW 91.19kDa.

Specification

• Description: This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
• Protein length: 592 amino acids
• Molecular Weight: 91.190kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKA LRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILA RNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVE EAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVST EMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFR KQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGA PGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAG AAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGAD RMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEA LTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQ KRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVK YTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWW LRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDED LIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFF PFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIIL AHTNLRLFHH
• Sequence Similarities: Belongs to the purH family.

Gene Information

• Gene Name: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [ Homo sapiens ]
• Official Symbol: ATIC
• Synonyms: ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; bifunctional purine biosynthesis protein PURH; AICARFT; IMPCHASE; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PURH
• Gene ID: 471
• mRNA Refseq: NM_004044
• Protein Refseq: NP_004035
• MIM: 601731
• Uniprot ID: P31939
• Chromosome Location: 2q35
• Pathway: Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, organism-specific biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, conserved biosystem; Metabolic pathways, organism-specific biosystem
• Function: IMP cyclohydrolase activity; hydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; protein homodimerization activity; transferase activity