Recombinant Human Breakpoint Cluster Region,GST-tagged
Cat.No. : |
BCR-1436H |
Product Overview : |
Recombinant human BCR (1-695) was expressed by baculovirus inSf9insect cellsusing an N-terminal GST tag. MW = 120kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : |
BCR-1436H |
Description : |
BCR (also known as breakpoint cluster region) encodes a phosphoprotein that has serine/threonine kinase activity. The human c-ABL oncogene is translocated from chromosome 9 to a region on chromosome 22 (associated with BCR) in chronic myelocytic leukemia. In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced comprising the BCR gene product plus the translocated c-ABL gene from chromosome 9. The BCR-ABL hybrid protein (p210) is formed that displays increased tyrosine kinase activity. A similar DNA rearrangement of the p210 protein is also found in cases of Philadelphia-positive acute lymphoblastic leukemia (ALL). |
Source : |
Sf9 insect cells using baculovirus. |
Sequence : |
1-695. |
Applications : |
Western Blot. |
Storage And Stability : |
Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : |
BCR breakpoint cluster region [ Homo sapiens ] |
Synonyms : |
BCR; breakpoint cluster region; ALL; CML; PHL; BCR1; D22S11; D22S662; FLJ16453 |
Gene ID : |
613 |
mRNA Refseq : |
NM_004327 |
Protein Refseq : |
NP_004318 |
MIM : |
151410 |
UniProt ID : |
P11274 |
Chromosome Location : |
22q11; 22q11.23 |
Pathway : |
Chronic myeloid leukemia; Pathways in cancer; Signaling by Rho GTPases |
Function : |
ATP binding; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity |
Products Types
Related Gene
BCR
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