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Recombinant Human BACE1

Cat.No. : BACE1-26297TH
Product Overview : Recombinant fragment, corresponding to amino acids 28-393 of Human BACE1.
  • Specification
  • Gene Information
  • Related Products
Description : Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
Source : E. coli
Tissue specificity : Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 0.3M Sodium chloride, 20mM Tris, 20mM Potassium chloride, pH 7.8
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the peptidase A1 family.
Gene Name : BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens ]
Official Symbol : BACE1
Synonyms : BACE1; beta-site APP-cleaving enzyme 1; BACE, beta site APP cleaving enzyme; beta-secretase 1;
Gene ID : 23621
mRNA Refseq : NM_001207048
Protein Refseq : NP_001193977
MIM : 604252
Uniprot ID : P56817
Chromosome Location : 11q23-q24
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;
Function : aspartic-type endopeptidase activity; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any potential side effects associated with BACE1 inhibition? 08/20/2021

Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.

How is BACE1 linked to Alzheimer's disease? 01/05/2020

BACE1 is implicated in Alzheimer's disease as it initiates the cleavage of APP, leading to the formation of beta-amyloid plaques, a hallmark of the disease.

How can BACE1 inhibitors potentially benefit Alzheimer's patients? 08/11/2018

BACE1 inhibitors may slow down or prevent the accumulation of beta-amyloid plaques, potentially delaying the progression of Alzheimer's disease.

Are there any ongoing clinical trials involving BACE1 inhibitors? 09/22/2017

Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.

Are there clinical applications of BACE1 inhibitors? 08/07/2016

Yes, BACE1 inhibitors are being explored as potential therapeutic agents for Alzheimer's disease to reduce the production of beta-amyloid peptides.

Customer Reviews (3)

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Reviews
07/27/2020

    Such support ensures researchers have access to reliable tools and expertise, facilitating their investigations into the functions, mechanisms, and disease relevance of BACE1 protein.

    12/23/2019

      A manufacturer can serve as a collaborative partner, engaging in discussions, and exchanging knowledge with researchers.

      09/30/2019

        Using BACE1 protein in trials provides advantages such as its involvement in cellular processes and its disease associations.

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