Recombinant Human BACE1, FLAG-tagged

• Cat.No.: BACE1-27426TH
• Product Overview: RecombinantBACE1 protein (Human), with a C-terminal DYKDDDDK-tag, extracellular domain.Expressed in HEK-293 cells

Specification

• Description: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
• Conjugation: FLAG
• Tissue specificity: Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
• Biological activity: Specific Activity: >10,000 units per mg protein.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM HEPES, 125mM Sodium chloride, pH 7.4
• Storage: Store at +4°C.
• Sequence Similarities: Belongs to the peptidase A1 family.

Gene Information

• Gene Name: BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens ]
• Official Symbol: BACE1
• Synonyms: BACE1; beta-site APP-cleaving enzyme 1; BACE, beta site APP cleaving enzyme; beta-secretase 1
• Gene ID: 23621
• mRNA Refseq: NM_001207048
• Protein Refseq: NP_001193977
• MIM: 604252
• Uniprot ID: P56817
• Chromosome Location: 11q23-q24
• Pathway: Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem
• Function: aspartic-type endopeptidase activity; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity