Recombinant Human CTNNB1,GST-tagged
Cat.No. : | CTNNB1-1441H |
Product Overview : | Recombinant full-length human Catenin beta was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 115kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CTNNB1-1441H |
Description : | β-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions. β-catenin interacts with TCF and LEF transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3β, form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of β-catenin by the proteasome. APC and Siah-1 mediate a novel β-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human β-catenin gene have been found in human colon cancer and melanomas. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa [ Homo sapiens ] |
Synonyms : | CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa; CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; beta-catenin; Catenin beta-1; Beta-catenin |
Gene ID : | 1499 |
mRNA Refseq : | NM_001098209 |
Protein Refseq : | NP_001091679 |
MIM : | 116806 |
UniProt ID : | P35222 |
Chromosome Location : | 3p21 |
Pathway : | Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Basal cell carcinoma; Colorectal cancer; Endometrial cancer; Focal adhesion; Leukocyte transendothelial migration; Melanogenesis; Pathogenic Escherichia coli infection; Pathways in cancer; Prostate cancer; Thyroid cancer; Tight junction; Wnt signaling pathway; Apoptosis; Cell-cell adhesion systems; Signaling by Wnt |
Function : | I-SMAD binding; alpha-catenin binding; androgen receptor binding; cadherin binding; chromatin binding; double-stranded DNA binding; kinase binding; promoter binding; protein C-terminus binding; protein phosphatase binding; signal transducer activity; transcription coactivator activity; transcription factor activity; transcription factor binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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