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Recombinant Human CREB Binding Protein, GST-tagged

Cat.No. : CREBBP-1442H
Product Overview : Recombinant human CBP (1319-1710) was expressed inE. colicells using a N-terminal GST tag. MW = 71kDa.
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Cat. No. : CREBBP-1442H
Description : CBP or CREB-binding protein is a nuclear transcriptional coactivator protein that binds specifically to the PKA-phosphorylated form of the CREB protein. Microinjection of an anti-CBP antiserum into fibroblasts leads to inhibition of transcription from a cAMP promoter. CBP can also cooperates with upstream activators, such as JUN. When JUN is phosphorylated at the transcriptionally stimulatory sites ser73 and ser63, it binds CBP with comparable affinity to CREB. Insulin signaling may directly regulate many cAMP signaling pathways at the transcriptional level by controlling CBP recruitment. Mutant CBP can be aberrantly recruited to CREB protein, resulting in inappropriate activation of gluconeogenesis and glucose intolerance.
Source : E.coli.
Sequence : 1319-1710.
Applications : Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : CREBBP CREB binding protein [ Homo sapiens ]
Synonyms : CREBBP; CREB binding protein; CBP; RSTS; KAT3A; Rubinstein-Taybi syndrome; RTS; CREB-binding protein
Gene ID : 1387
mRNA Refseq : NM_001079846
Protein Refseq : NP_001073315
MIM : 600140
UniProt ID : Q92793
Chromosome Location : 16p13.3
Pathway : Adherens junction; Cell cycle; Huntington"s disease; Jak-STAT signaling pathway; Long-term potentiation; Notch signaling pathway; Pathways in cancer; Prostate cancer; Renal cell carcinoma; Melanogenesis; TGF-beta signaling pathway; Wnt signaling pathway; Gene Expression; Metabolism of lipids and lipoproteins
Function : MyoD binding; SMAD binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; p53 binding; peroxisome proliferator activated receptor binding; signal transducer activity; transcription coactivator activity; transcription coactivator activity; transcription factor activity; transferase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Why is the discovery of new CREBBP inhibitors urgent? 07/20/2022

Discovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.

What is the significance of the bromodomain in CREBBP? 06/27/2022

The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.

What does CREBBP stand for? 08/25/2020

CREBBP stands for CREB-binding protein.

What is the role of CREBBP in cellular function? 03/19/2019

CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.

What is the current status of CREBBP small molecule inhibitors? 04/03/2016

Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.

In which category of structural domain proteins does CREBBP belong? 02/14/2016

CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.

How many structural domains does CREBBP have? 02/01/2016

CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.

Customer Reviews (3)

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Reviews
04/17/2021

    The product's adaptability to custom protocols empowered us to explore innovative experimental setups.

    01/29/2019

      The reduced environmental impact of the product was a responsible choice that resonated with our values.

      11/15/2016

        Customized solutions offered by the manufacturer increased the product's utility in our research.

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