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Recombinant Human BLK, His-tagged

Cat.No. : BLK-26112TH
Product Overview : Recombinant full length Human BLK with an N terminal His tag 59.8 kDa.
  • Specification
  • Gene Information
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Description : This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
Protein length : 505 amino acids
Conjugation : HIS
Molecular Weight : 59.800kDa inclusive of tags
Source : Baculovirus infected High-5 cells
Tissue specificity : Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 30% Glycerol, 0.58% Sodium chloride, 0.02% DTT, 0.002% PMSF
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMGLVS SKKPDKEKPIKEKDKGQWSPLKVSA QDKDAPPLPPLVVFNHLTPPPPDEH LDEDKHFVVALYDYTAMNDRDLQML KGEKLQVLKGTGDWWLARSLVTGRE GYVPSNFVARVESLEMERWFFRSQG RKEAERQLLAPINKAGSFLIRESET NKGAFSLSVKDVTTQGELIKHYKIR CLDEGGYYISPRITFPSLQALVQHY SKKGDGLCQRLTLPCVRPAPQNPWA QDEWEIPRQSLRLVRKLGSGQFGEV WMGYYKNNMKVAIKTLKEGTMSPEA FLGEANVMKALQHERLVRLYAVVTK EPIYIVTEYMARGCLLDFLKTDEGS RLSLPRLIDMSAQIAEGMAYIERMN SIHRDLRAANILVSEALCCKIADFG LARIIDSEYTAQEGAKFPIKWTAPE AIHFGVFTIKADVWSFGVLLMEVVT YGRVPYPGMSNPEVIRNLERGYRMP RPDTCPPELYRGVIAECWRSRPEER PTFEFLQSVLEDFYTATERQYELQP
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.Contains 1 protein kinase domain.Contains 1 SH2 domain.Contains 1 SH3 domain.
Gene Name : BLK B lymphoid tyrosine kinase [ Homo sapiens ]
Official Symbol : BLK
Synonyms : BLK; B lymphoid tyrosine kinase; tyrosine-protein kinase Blk; MGC10442;
Gene ID : 640
mRNA Refseq : NM_001715
Protein Refseq : NP_001706
MIM : 191305
Uniprot ID : P51451
Chromosome Location : 8p23-p22
Pathway : Alpha-synuclein signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem; EPHA forward signaling, organism-specific biosystem;
Function : ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein tyrosine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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