Recombinant Human C5AR1

• Cat.No.: C5AR1-27120TH
• Product Overview: Recombinant full length Human C5R1 with N terminal FLAG tag and C terminal His tag co-expressed with inhibitory G-protein Gia1b1g2, prepared from Sf9 insect cells triple-infected with C5R1, Gia1 and Gb1g2 encoding baculoviruses.

Specification

• Description: C5R1 belongs to the G-protein coupled receptor 1 family and is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release and superoxide anion production.Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
• Conjugation: FLAG,His
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: C5AR1 complement component 5a receptor 1 [ Homo sapiens ]
• Official Symbol: C5AR1
• Synonyms: C5AR1; complement component 5a receptor 1; C5R1, complement component 5 receptor 1 (C5a ligand); C5a anaphylatoxin chemotactic receptor; C5A; C5AR; CD88
• Gene ID: 728
• mRNA Refseq: NM_001736
• Protein Refseq: NP_001727
• MIM: 113995
• Uniprot ID: P21730
• Chromosome Location: 19q13.3-q13.4
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem
• Function: C5a anaphylatoxin receptor activity; G-protein coupled receptor activity; receptor activity; signal transducer activity