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Recombinant Human CAPN1, His-tagged

Cat.No. : CAPN1-27399TH
Product Overview : Recombinant fragment, corresponding to amino acids 214-500 of Human Calpain 1 with N terminal His tag; 287 amino acids, 33kDa.
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Description : The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
Conjugation : HIS
Source : E. coli
Tissue specificity : Ubiquitous.
Form : Lyophilised:Reconstitute with 121 μl distilled water.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : FEDFTGGVTEWYELRKAPSDLYQII LKALERGSLLGCSID ISSVLDMEAITFKKLVKGHAYSVTG AKQVNYRGQVVSL IRMRNPWGEVEWTGAWSDSSSEWNN VDPYERDQLRVKMEDGEFWMSFRDF MREFTRLEICNLTPDALKSRTIRKW NTT LYEGTWRRGSTAGGCRNYPATFWVN PQFKIRLDETDDP DDYGDRESGCSFVLALMQKHRRRER RFGRDMETIGFAVYE VPPELVGQPAVHLKRDFFLANASRA RSEQFINLREVST RFRLPPGEYVVVPST
Sequence Similarities : Belongs to the peptidase C2 family.Contains 1 calpain catalytic domain.Contains 4 EF-hand domains.
Gene Name : CAPN1 calpain 1, (mu/I) large subunit [ Homo sapiens ]
Official Symbol : CAPN1
Synonyms : CAPN1; calpain 1, (mu/I) large subunit; calpain-1 catalytic subunit; CANP; CANPL1; muCANP; muCL;
Gene ID : 823
mRNA Refseq : NM_001198868
Protein Refseq : NP_001185797
MIM : 114220
Uniprot ID : P07384
Chromosome Location : 11q13
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Focal Adhesion, organism-specific biosystem;
Function : calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; peptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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