Recombinant Human CDKN2C, GST-tagged

• Cat.No.: CDKN2C-1475H
• Product Overview: Recombinant full-length human p18INK4C was expressed inE. colicells using an N-terminal GST tag. MW = 42 kDa.

Specification

• Cat. No.: CDKN2C-1475H
• Description: p18INK4C is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6. Mutation of p18INK4C impairs B-cell terminal differentiation and confers increased susceptibility to tumor development. p18INK4C can function as a tumor suppressor gene in Hodgkins lymphoma and its inactivation may contribute to the cell cycle deregulation and defective terminal differentiation characteristic of the Reed-Sternberg cells.
• Source: E. coli.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [ Homo sapiens ]
• Synonyms: CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18; INK4C; p18-INK4C; cyclin-dependent kinase inhibitor 2C; CDK6 inhibitor p18; OTTHUMP00000009731; cyclin-dependent inhibitor; cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase 6 inhibitor p18; CDKN6; OTTHUMP00000009730; OTTHUMP00000046546; p18-INK4c; p18-INK6; Cyclin-dependent kinase 6 inhibitor
• Gene ID: 1031
• mRNA Refseq: NM_001262
• Protein Refseq: NP_001253
• MIM: 603369
• UniProt ID: P42773
• Chromosome Location: 1p32
• Pathway: Cell cycle
• Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding