Recombinant Human TGFBR1, GST-tagged

• Cat.No.: TGFBR1-1499H
• Product Overview: Recombinant human TGFbetaR1 (80-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 65 kDa.

Specification

• Cat. No.: TGFBR1-1499H
• Description: TGFβR1 is a transmembrane serine/threonine protein kinase and a member of the TGFβ receptor subfamily. TGFβ regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFβR2 and activation of TGFβR1. TGFβR1 may be inactivated in many of the cases of human tumor cells refractory to TGFβ-mediated cell cycle arrest. Heterozygous mutations in TGFβR1 and TGFβR2 have been reported in Loeys-Dietz aortic aneurysm syndrome (LDS) and also dominant TGFβR2 mutations have been identified in Marfan syndrome type 2 (MFS2) and familial thoracic aortic aneurysms and dissections (TAAD). Mutations of TGFβR1 and TGFβR2 are associated with atherosclerosis and several human cancers.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 80-end.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ]
• Synonyms: TGFBR1; transforming growth factor, beta receptor 1; AAT5; ALK5; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; 9q22; activin receptor-like kinase 5; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53Kd; activin A receptor type II-like kinase, 53kDa; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); EC 2.7.11.30; TGF-beta receptor type-1; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TGF-beta type I receptor; TbetaR-I; OTTHUMP00000021783
• Gene ID: 7046
• mRNA Refseq: NM_001130916
• Protein Refseq: NP_001124388
• MIM: 190181
• UniProt ID: P36897
• Chromosome Location: 9q22
• Pathway: Adherens junction; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; TGF-beta signaling pathway
• Function: ATP binding; SMAD binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein complex binding; protein heterodimerization activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; type II transforming growth factor beta receptor binding; ubiquitin protein ligase binding