Recombinant Human TRAF2 Protein, GST-tagged

• Cat.No.: TRAF2-1500H
• Product Overview: Recombinant full-length human TRAF2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily. TRAF2 is involved in TNF-alpha-mediated activation of MAPK8/JNK and NF-κB pathway. TRAF2 interacts with TNF receptors and forms a heterodimeric complex with TRAF1. The TRAF1-TRAF2 complex interacts with IAPs to mediate the anti-apoptotic signals from TNF receptors. TRAF2 also interacts with TRADD, a TNF receptor associated apoptotic signal transducer, to ensure the recruitment of IAPs for the direct inhibition of caspase activation
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Molecular Mass: 89 kDa
• Purity: >70%
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Gene Information

• Gene Name: TRAF2 TNF receptor-associated factor 2 [ Homo sapiens ]
• Official Symbol: TRAF2
• Synonyms: TRAF2; TNF receptor-associated factor 2; TRAP3; E3 ubiquitin-protein ligase TRAF2; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3; TRAP; MGC:45012
• Gene ID: 7186
• mRNA Refseq: NM_021138
• Protein Refseq: NP_066961
• MIM: 601895
• UniProt ID: Q12933