Recombinant Human CDH12

• Cat.No.: CDH12-26803TH
• Product Overview: Recombinant fragment of Human CDH12, amino acids 372-470 with a N terminal proprietary tag; Predicted MWt 36.52 kDa.

Specification

• Description: This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
• Protein length: 99 amino acids
• Molecular Weight: 36.520kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Brain.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: KISVLDVDEPPVFSKPLYTMEVYED TPVGTIIGAVTAQDLDVGSSAVRYF IDWKSDGDSYFTIDGNEGTIATNEL LDRESTAQYNFSIIASKVSNPLLT
• Sequence Similarities: Contains 5 cadherin domains.

Gene Information

• Gene Name: CDH12 cadherin 12, type 2 (N-cadherin 2) [ Homo sapiens ]
• Official Symbol: CDH12
• Synonyms: CDH12; cadherin 12, type 2 (N-cadherin 2); cadherin-12; Br cadherin; CDHB
• Gene ID: 1010
• mRNA Refseq: NM_004061
• Protein Refseq: NP_004052
• MIM: 600562
• Uniprot ID: P55289
• Chromosome Location: 5p14.3
• Pathway: Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem
• Function: calcium ion binding