Recombinant Human CDH1
Cat.No. : | CDH1-26935TH |
Product Overview : | Recombinant fusion protein fragment (fused to a proprietary tag), corresponding to amino acids 600-707 of Human E Cadherin |
- Specification
- Gene Information
- Related Products
Description : | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. |
Source : | E. coli |
Tissue specificity : | Non-neural epithelial tissues. |
Form : | Liquid |
Purity : | Purified via His tag |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Contains 5 cadherin domains. |
Gene Name : | CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens ] |
Official Symbol : | CDH1 |
Synonyms : | CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; cadherin-1; CD324; E Cadherin; uvomorulin; |
Gene ID : | 999 |
mRNA Refseq : | NM_004360 |
Protein Refseq : | NP_004351 |
MIM : | 192090 |
Uniprot ID : | P12830 |
Chromosome Location : | 16q22.1 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Apoptosis, organism-specific biosystem; |
Function : | GTPase activating protein binding; RPTP-like protein binding; beta-catenin binding; calcium ion binding; cell adhesion molecule binding; |
Products Types
◆ Recombinant Protein | ||
CDH1-3118H | Recombinant Human CDH1 Protein, MYC/DDK-tagged | +Inquiry |
CDH1-207H | Recombinant Human CDH1 Protein, His-tagged | +Inquiry |
CDH1-41H | Recombinant Human CDH1 Protein, C-8His tagged, Biotinylated | +Inquiry |
CDH1-2645H | Recombinant Human CDH1 protein(791-880 aa), C-His-tagged | +Inquiry |
CDH1-0969H | Recombinant Human CDH1 Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CDH1-736RCL | Recombinant Rat CDH1 cell lysate | +Inquiry |
CDH1-1892MCL | Recombinant Mouse CDH1 cell lysate | +Inquiry |
CDH1-938HCL | Recombinant Human CDH1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionCDH1 gene mutations are usually passed on in an autosomal dominant manner, depending on the type and location of the mutation.
Carriers of CDH1 gene mutations should have gastroscopy, ultrasonography, and other related tests to monitor the development and progression of stomach cancer.
For people with mutations in the CDH1 gene, prophylactic total gastrectomy may reduce the risk of diffuse stomach cancer. There is currently no specific treatment to target CDH1 gene mutations.
CDH1 gene mutation is closely related to the occurrence of diffuse gastric cancer, which is a special subtype of gastric cancer with a high degree of invasion and malignancy.
The CDH1 gene encodes a protein called E-calcin that plays an important role in cell adhesion and tissue differentiation. Mutations in the CDH1 gene may affect these processes, resulting in abnormal cell adhesion and tissue differentiation.
CDH1 gene mutations may be associated with the development of a small number of breast cancers, because CDH1 also plays a role in regulating cell adhesion and tissue structure in breast tissue.
Customer Reviews (3)
Write a reviewThis recombinant protein has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.
The protein was highly purified and was not doped with other proteins or impurities.
CDH1 has similar activity to the native protein and is able to perform the expected biological functions.
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