Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CDH1

Cat.No. : CDH1-26935TH
Product Overview : Recombinant fusion protein fragment (fused to a proprietary tag), corresponding to amino acids 600-707 of Human E Cadherin
  • Specification
  • Gene Information
  • Related Products
Description : This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Source : E. coli
Tissue specificity : Non-neural epithelial tissues.
Form : Liquid
Purity : Purified via His tag
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Contains 5 cadherin domains.
Gene Name : CDH1 cadherin 1, type 1, E-cadherin (epithelial) [ Homo sapiens ]
Official Symbol : CDH1
Synonyms : CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; cadherin-1; CD324; E Cadherin; uvomorulin;
Gene ID : 999
mRNA Refseq : NM_004360
Protein Refseq : NP_004351
MIM : 192090
Uniprot ID : P12830
Chromosome Location : 16q22.1
Pathway : Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Apoptosis, organism-specific biosystem;
Function : GTPase activating protein binding; RPTP-like protein binding; beta-catenin binding; calcium ion binding; cell adhesion molecule binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How about the inheritance pattern of CDH1 gene mutations? 09/25/2019

CDH1 gene mutations are usually passed on in an autosomal dominant manner, depending on the type and location of the mutation.

What screening is required for carriers of CDH1 gene mutations? 08/03/2019

Carriers of CDH1 gene mutations should have gastroscopy, ultrasonography, and other related tests to monitor the development and progression of stomach cancer.

Can CDH1 gene mutations be prevented or treated? 06/14/2019

For people with mutations in the CDH1 gene, prophylactic total gastrectomy may reduce the risk of diffuse stomach cancer. There is currently no specific treatment to target CDH1 gene mutations.

Which gastric cancer subtypes are associated with CDH1 mutations? 04/21/2019

CDH1 gene mutation is closely related to the occurrence of diffuse gastric cancer, which is a special subtype of gastric cancer with a high degree of invasion and malignancy.

What are the effects of CDH1 gene mutations on cell adhesion and tissue differentiation? 04/01/2019

The CDH1 gene encodes a protein called E-calcin that plays an important role in cell adhesion and tissue differentiation. Mutations in the CDH1 gene may affect these processes, resulting in abnormal cell adhesion and tissue differentiation.

What is the relationship between CDH1 gene mutations and breast cancer? 03/24/2019

CDH1 gene mutations may be associated with the development of a small number of breast cancers, because CDH1 also plays a role in regulating cell adhesion and tissue structure in breast tissue.

Customer Reviews (3)

Write a review
Reviews
04/22/2022

    This recombinant protein has a very short half-life and shows a very high clearance rate, which makes its biological activity more stable.

    05/27/2020

      The protein was highly purified and was not doped with other proteins or impurities.

      05/21/2019

        CDH1 has similar activity to the native protein and is able to perform the expected biological functions.

        Ask a Question for All CDH1 Products

        Required fields are marked with *

        My Review for All CDH1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends