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Recombinant Human CDK4

Cat.No. : CDK4-27905TH
Product Overview : Recombinant full length human CDK4 protein containing an N-terminal tag
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Source : E. coli
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Contains 1 protein kinase domain.
Gene Name : CDK4 cyclin-dependent kinase 4 [ Homo sapiens ]
Official Symbol : CDK4
Synonyms : CDK4; cyclin-dependent kinase 4; PSK J3;
Gene ID : 1019
mRNA Refseq : NM_000075
Protein Refseq : NP_000066
MIM : 123829
Uniprot ID : P11802
Chromosome Location : 12q13
Pathway : ATF-2 transcription factor network, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem;
Function : ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; protein kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any potential challenges in targeting CDK4 for cancer therapy? 11/24/2022

Resistance to CDK4 inhibitors and the need for patient stratification are some of the challenges in using CDK4 as a therapeutic target.

Can CDK4 be targeted for cancer therapy? 06/16/2022

Yes, CDK4 is a target for cancer therapy, and drugs that inhibit CDK4 have been developed for the treatment of specific cancers.

How is CDK4 clinically relevant? 06/30/2020

CDK4 is clinically relevant because it plays a crucial role in the development and progression of various cancers.

Which cancers are commonly associated with CDK4 overactivity? 06/19/2020

CDK4 overactivity is commonly associated with breast cancer, melanoma, and liposarcoma.

How does CDK4 relate to cell senescence? 05/31/2016

CDK4 can promote cell senescence, a state of irreversible growth arrest, which has implications in cancer therapy.

Customer Reviews (3)

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Reviews
02/18/2023

    Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the CDK4 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.

    02/16/2020

      They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the CDK4 protein.

      05/29/2018

        The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.

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