Recombinant Human CHUK
Cat.No. : | CHUK-27562TH |
Product Overview : | Recombinant full length Human IKK alpha with a N terminal proprietary tag; molecular weight 114 kDa including tag. |
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- Gene Information
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Description : | This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. |
Protein length : | 745 amino acids |
Molecular Weight : | 114.000kDa inclusive of tags |
Source : | Baculovirus infected sf9 cells |
Tissue specificity : | Widely expressed. |
Biological activity : | Specific activity is 2.5nm/min/mg |
Form : | Liquid |
Purity : | Densitometry |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.Contains 1 protein kinase domain. |
Publication : |
Quantitation of the Dynamic Profiles of the Innate Immune Response Using Multiplex Selected Reaction Monitoring–Mass Spectrometry (2013)
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Gene Name : | CHUK conserved helix-loop-helix ubiquitous kinase [ Homo sapiens ] |
Official Symbol : | CHUK |
Synonyms : | CHUK; conserved helix-loop-helix ubiquitous kinase; TCF16; inhibitor of nuclear factor kappa-B kinase subunit alpha; IkBKA; IKK alpha; IKK1; IKKA; NFKBIKA; |
Gene ID : | 1147 |
mRNA Refseq : | NM_001278 |
Protein Refseq : | NP_001269 |
MIM : | 600664 |
Uniprot ID : | O15111 |
Chromosome Location : | 10q24-q25 |
Pathway : | AKT phosphorylates targets in the cytosol, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; |
Function : | ATP binding; IkappaB kinase activity; nucleotide binding; protein binding; protein kinase activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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