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Recombinant Human CLDN4

Cat.No. : CLDN4-26708TH
Product Overview : Recombinant fragment of Human Claudin 4 (amino acids 29-78) with proprietary tag, 31.13kDa.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Protein length : 50 amino acids
Molecular Weight : 31.130kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MWRVTAFIGSNIVTSQTIWEGLWMN CVVQSTGQMQCKVYDSLLALPQDLQ
Sequence Similarities : Belongs to the claudin family.
Gene Name : CLDN4 claudin 4 [ Homo sapiens ]
Official Symbol : CLDN4
Synonyms : CLDN4; claudin 4; CPETR, CPETR1; claudin-4; Clostridium perfringens enterotoxin receptor 1; CPE R; hCPE R; WBSCR8; Williams Beuren syndrome chromosomal region 8 protein;
Gene ID : 1364
mRNA Refseq : NM_001305
Protein Refseq : NP_001296
MIM : 602909
Uniprot ID : O14493
Chromosome Location : 7q11.23
Pathway : Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem;
Function : identical protein binding; structural molecule activity; transmembrane signaling receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential therapeutic implications of targeting CLDN4 in cancer treatment? 10/10/2022

Inhibiting CLDN4 function could enhance the efficacy of existing cancer therapies and potentially lead to the development of new treatment strategies.

How does CLDN4 protein contribute to the pathogenesis of infectious diseases? 01/16/2021

CLDN4 is involved in regulating the entry of certain pathogens into host cells, making it a potential target for the development of antiviral and antibacterial therapies.

Can CLDN4 protein be targeted for the treatment of autoimmune diseases? 10/01/2017

Research is underway to explore the potential of targeting CLDN4 to modulate tissue barrier function and alleviate the symptoms of autoimmune diseases.

How can CLDN4 protein be utilized in the diagnosis and management of IBD? 09/06/2017

Monitoring CLDN4 levels and function may provide valuable insights into the progression of IBD and help in the development of targeted therapies.

In what other clinical settings is CLDN4 protein being investigated? 08/18/2017

CLDN4 is also being studied in the context of kidney disease, skin disorders, and neurodegenerative diseases due to its role in maintaining tissue barrier function.

Customer Reviews (3)

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Reviews
08/05/2021

    The CLDN4 protein showcases outstanding quality, ensuring its suitability for addressing my experimental requirements effectively.

    06/02/2019

      the manufacturer's dedication to excellent technical support assures me that any challenges or obstacles I encounter will be swiftly resolved.

      06/25/2016

        Its top-notch purity and integrity instill confidence in obtaining precise and reliable data, thereby enabling significant advancements in my research.

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