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Recombinant Human COL18A1

Cat.No. : COL18A1-28560TH
Product Overview : Human Recombinant Full Length Endostatin produced in Pichia Pastoris.A single, glycosylated, polypeptide having a total molecular weight of20 kDa.
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  • Gene Information
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Description : This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tissue specificity : Present in multiple organs with highest levels in liver, lung and kidney.
Biological activity : The activity calculated by ECE migration inhibition was found to be 50,000IU/mg.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : Amino Acid Composition is in total agreement with the expected amino acid composition of native human Endostatin.
Sequence Similarities : Belongs to the multiplexin collagen family.Contains 1 FZ (frizzled) domain.Contains 1 TSP N-terminal (TSPN) domain.
Gene Name : COL18A1 collagen, type XVIII, alpha 1 [ Homo sapiens ]
Official Symbol : COL18A1
Synonyms : COL18A1; collagen, type XVIII, alpha 1; KNO, Knobloch syndrome, type 1; collagen alpha-1(XVIII) chain; endostatin; KNO1; KS;
Gene ID : 80781
mRNA Refseq : NM_030582
Protein Refseq : NP_085059
MIM : 120328
Uniprot ID : P39060
Chromosome Location : 21q22.3
Pathway : Direct p53 effectors, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem;
Function : metal ion binding; protein binding; structural molecule activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you discuss the role of COL18A1 in neurobiology, particularly its involvement in the central nervous system and potential implications for neurodegenerative disorders? 04/16/2021

COL18A1 has roles in the central nervous system. Understanding its functions provides insights into potential implications for neurodegenerative disorders and neural tissue development.

In angiogenesis, how does COL18A1 influence blood vessel formation, and what molecular mechanisms are involved in its regulation of endothelial cell behavior? 06/02/2020

COL18A1 plays a role in angiogenesis by regulating endothelial cell behavior. It interacts with integrins and growth factors, influencing signaling pathways essential for blood vessel formation.

What evidence supports the involvement of COL18A1 mutations in human diseases, and how do these mutations impact COL18A1 function and tissue homeostasis? 01/19/2019

Mutations in COL18A1 are associated with various diseases. Understanding the impact of these mutations on collagen XVIII function provides insights into their roles in tissue homeostasis and disease pathology.

How does COL18A1 contribute to the regulation of cellular senescence, and are there implications for age-related diseases and tissue degeneration? 12/30/2018

COL18A1 has been implicated in the regulation of cellular senescence. Understanding its role in age-related diseases may provide insights into tissue degeneration and potential therapeutic targets.

In cancer progression, how does COL18A1 influence tumor behavior, metastasis, and interactions with the tumor microenvironment? 08/11/2018

COL18A1 is implicated in cancer progression, affecting tumor behavior and metastasis. Its interactions within the tumor microenvironment contribute to the regulation of invasive phenotypes.

Customer Reviews (3)

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Reviews
06/01/2022

    The delivery was well-coordinated and timely.

    09/12/2019

      Superior quality resonates in this lab product, supported by customer service that is genuinely helpful.

      12/23/2018

        The lab product showcases commendable quality.

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