Recombinant Human COL18A1
Cat.No. : | COL18A1-28560TH |
Product Overview : | Human Recombinant Full Length Endostatin produced in Pichia Pastoris.A single, glycosylated, polypeptide having a total molecular weight of20 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Tissue specificity : | Present in multiple organs with highest levels in liver, lung and kidney. |
Biological activity : | The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: PBS |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | Amino Acid Composition is in total agreement with the expected amino acid composition of native human Endostatin. |
Sequence Similarities : | Belongs to the multiplexin collagen family.Contains 1 FZ (frizzled) domain.Contains 1 TSP N-terminal (TSPN) domain. |
Gene Name : | COL18A1 collagen, type XVIII, alpha 1 [ Homo sapiens ] |
Official Symbol : | COL18A1 |
Synonyms : | COL18A1; collagen, type XVIII, alpha 1; KNO, Knobloch syndrome, type 1; collagen alpha-1(XVIII) chain; endostatin; KNO1; KS; |
Gene ID : | 80781 |
mRNA Refseq : | NM_030582 |
Protein Refseq : | NP_085059 |
MIM : | 120328 |
Uniprot ID : | P39060 |
Chromosome Location : | 21q22.3 |
Pathway : | Direct p53 effectors, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; |
Function : | metal ion binding; protein binding; structural molecule activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCOL18A1 has roles in the central nervous system. Understanding its functions provides insights into potential implications for neurodegenerative disorders and neural tissue development.
COL18A1 plays a role in angiogenesis by regulating endothelial cell behavior. It interacts with integrins and growth factors, influencing signaling pathways essential for blood vessel formation.
Mutations in COL18A1 are associated with various diseases. Understanding the impact of these mutations on collagen XVIII function provides insights into their roles in tissue homeostasis and disease pathology.
COL18A1 has been implicated in the regulation of cellular senescence. Understanding its role in age-related diseases may provide insights into tissue degeneration and potential therapeutic targets.
COL18A1 is implicated in cancer progression, affecting tumor behavior and metastasis. Its interactions within the tumor microenvironment contribute to the regulation of invasive phenotypes.
Customer Reviews (3)
Write a reviewThe delivery was well-coordinated and timely.
Superior quality resonates in this lab product, supported by customer service that is genuinely helpful.
The lab product showcases commendable quality.
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